BRL-15572 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BRL-15572 是一种有效的、选择性的 h5-HT1D 受体拮抗剂。

BRL-15572 is a potent, selective h5-HT1D receptor antagonist with pKi of 7.9, dispalys 60-fold selectivity over h5-HT1B; shows binding affinities for 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 with pKi of 7.7, 6.1, 5.2, 6.0, 6.6, 7.4, 6.2, 5.9 and 6.3, respectively.

BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells.BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors.

BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test.BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig.

BRL15572 | BRL 15572

Endocrinology/Hormones

5-HT Receptor

5-HT1A| 5-HT1D| 5-HT2A| 5-HT2B| 5-HT7

Neurological Disease

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193611-72-2

479.8696

C25H29Cl3N2O

>98% (HPLC)

10 mM in DMSO

C1CN(CCN1CC(C(C2=CC=CC=C2)C3=CC=CC=C3)O)C4=CC(=CC=C4)Cl.Cl.Cl

1-Piperazineethanol, 4-(3-chlorophenyl)-.alpha.-(diphenylmethyl)-, hydrochloride (1:2)

(-20℃)

With Ice Pack

≥ 2 years